Most weight loss injections target one appetite hormone. Mounjaro (tirzepatide) targets two: GLP-1 and GIP. Both signal your brain to reduce hunger. Together they create an appetite-suppressing effect no single-hormone treatment has matched.
SURMOUNT-1 documented this: 2,539 participants, 72 weeks, average loss of 20.9% at 15mg. For a 90kg person, that is roughly 19kg.
Mounjaro (tirzepatide) is a dual GIP and GLP-1 receptor agonist available via private prescription in Malaysia. Unlike semaglutide (Ozempic/Wegovy/Rybelsus), Mounjaro activates two gut hormone pathways simultaneously, making it significantly more effective for weight loss. Clinical trials (SURMOUNT programme) showed average weight reduction of 15–22.5% of body weight over 72 weeks — the highest weight loss efficacy recorded for any approved weight loss medication to date.
All three medications are injectable GLP-1-based weight loss treatments — with a key distinction for Mounjaro. Ozempic and Rybelsus (semaglutide) activate only the GLP-1 receptor. Mounjaro (tirzepatide) additionally activates the GIP receptor, which works synergistically to reduce appetite more powerfully, improve insulin sensitivity further, and promote greater fat loss. In head-to-head trials, Mounjaro produces significantly greater weight loss than semaglutide-based medications.
In the SURMOUNT-1 clinical trial, participants without diabetes lost an average of 15.0% (5mg), 19.5% (10mg), and 20.9% (15mg) of their body weight over 72 weeks. Real-world results vary, but many patients achieve 15–25% weight reduction. A person weighing 90kg could expect to lose 13–23kg over the treatment period. Weight maintenance after stopping requires sustained lifestyle changes — ongoing treatment or transition to a lower-dose maintenance programme may be needed.
The most commonly reported side effects are gastrointestinal: nausea, vomiting, diarrhoea, constipation, and reduced appetite — particularly during dose escalation. These typically improve after the first few weeks. Starting at the lowest dose (2.5mg) and increasing slowly every 4 weeks helps minimise side effects. Serious but rare risks include pancreatitis and, theoretically, thyroid C-cell tumours (based on animal studies). A full medical assessment is done before prescribing.
Yes. Mounjaro is a prescription-only medication in Malaysia. At Vivardi Clinics, our doctors conduct a full metabolic assessment — including BMI, blood glucose, HbA1c, and medical history review — before prescribing Mounjaro. Regular monthly follow-ups are required to monitor weight, side effects, and metabolic markers throughout treatment. We also provide dietary guidance to maximise results during treatment.