Plinest is an injectable polynucleotide (PN) treatment derived from highly purified DNA fragments (from trout or salmon sperm). Polynucleotides work by activating fibroblasts — the cells responsible for producing collagen, elastin, and hyaluronic acid — and by providing a biostimulating scaffold that supports tissue repair and regeneration. Unlike simple hydration fillers, Plinest produces genuine biological tissue remodelling, improving skin density, elasticity, and hydration from within.
Plinest is highly effective for fine lines and skin laxity (especially under-eye hollows and the neck), dehydrated or thin skin with loss of elasticity, acne scar remodelling (when combined with other procedures), skin damaged by sun, ageing, or previous harsh treatments, and dull, tired-looking complexion. It is a versatile regenerative treatment suitable for face, neck, hands, and décolletage — essentially anywhere the skin needs deep repair and quality improvement.
Profhilo and HA skin boosters primarily work through deep hydration and indirect collagen stimulation via HA molecules. Plinest polynucleotides have a different mechanism — they directly stimulate fibroblast DNA repair and new collagen synthesis at a cellular level, without relying on hydration. The two approaches are complementary: many patients combine Plinest (for deep tissue regeneration) with Profhilo (for intense hydration) for superior overall skin quality improvement.
A standard Plinest protocol involves 3–4 sessions spaced 2–3 weeks apart. Results become progressively visible over the 2–3 months following treatment as new collagen matures. Most patients notice firmer, smoother, more hydrated skin with a reduction in fine lines. Results last approximately 9–12 months, with maintenance sessions recommended 1–2 times per year to sustain the skin quality improvements.
Plinest polynucleotide treatment at Vivardi Clinics is priced per session. Each session typically uses 1–2 vials depending on the treatment area. Pricing reflects the premium quality of the Plinest product (manufactured in Italy by Mastelli) and the expertise required for correct injection technique. Contact Vivardi Clinics for current session pricing and available package deals for course treatments.