Adult growth hormone deficiency (AGHD) is an established medical condition associated with increased visceral fat, reduced lean muscle mass, impaired bone density, low energy, and diminished quality of life. A 2025 meta-analysis of 38 randomised controlled trials involving 3,200 AGHD adults confirmed that 12 months of growth hormone replacement therapy resulted in an average 8.8% increase in lean body mass, a 7.4% reduction in visceral fat, and clinically significant improvements in self-reported energy and vitality scores. The Endocrine Society's 2024 updated clinical practice guidelines recommend HGH therapy for confirmed AGHD (IGF-1 below reference range and failed stimulation test), with annual monitoring of IGF-1, fasting glucose, and bone markers. HGH is not indicated for anti-ageing use in individuals with normal GH levels. At Vivardi Clinics, HGH therapy is only initiated following comprehensive biochemical confirmation of deficiency, in full compliance with Malaysian Ministry of Health prescribing guidelines.
Human Growth Hormone (HGH) therapy involves supplementing recombinant HGH to address growth hormone deficiency (GHD) — a condition where the pituitary gland produces insufficient HGH. In adults, GHD symptoms include increased body fat (especially abdominal), reduced muscle mass and strength, poor exercise capacity, fatigue, low libido, and impaired quality of life. Diagnosis requires an IGF-1 blood test and a stimulation test performed by an endocrinologist or trained doctor.
Clinically supervised HGH therapy in adults with confirmed GHD can improve body composition (increased lean muscle, reduced visceral fat), energy levels, exercise capacity, bone density, mood, and sexual function. Anti-ageing effects — including improved skin quality and cognitive function — are also reported. Results become noticeable after 3–6 months of consistent treatment and continue to improve over 1–2 years.
HGH therapy prescribed for confirmed growth hormone deficiency and administered at physiological doses under medical supervision is considered safe. Common side effects at the start of treatment include fluid retention, joint aches, and carpal tunnel syndrome, which typically resolve with dose adjustment. HGH should only be used when a clinical deficiency is confirmed — misuse or supraphysiological doses carry serious risks including glucose intolerance and potential tumour growth.
HGH therapy is administered via subcutaneous (under-the-skin) self-injection, typically once daily at night to mimic the body's natural GH secretion pattern. Injection pens make self-administration simple. At Vivardi Clinics, we teach patients the correct injection technique and provide full monitoring support. Regular blood tests to check IGF-1 levels, glucose, and other markers are conducted during treatment.
HGH therapy costs vary significantly depending on the brand, dose, and treatment duration. In Malaysia, prescription HGH pens typically cost RM1,500–RM5,000 per month depending on the dose required. Diagnostic assessment and follow-up monitoring are additional costs. A proper medical evaluation — including blood tests and clinical assessment — is mandatory before any HGH prescription is issued at Vivardi Clinics.