QR678 Neo After PRP Hair Treatment: Can You Combine Both and What Is the Right Sequence?

Hair Regrowth · QR678 Neo + PRP · Rawang Selangor

Patients already doing PRP often ask whether QR678 Neo can be added. Patients doing QR678 Neo ask whether PRP adds value. The answer to both is yes — but the reason, the sequencing, and the realistic expectations matter.

📅 May 2026  |  Vivardi Clinics, Rawang

Among the most common questions at a hair loss consultation is this: “I am already doing PRP — should I add QR678 Neo? Or I am doing QR678 Neo — does PRP add anything?” It is the right question to ask. Both treatments target hair follicle biology through growth factor delivery, but they do so through different mechanisms, using different growth factor profiles, and with different evidence bases. Understanding the biology of each makes it clear why combining them makes clinical sense — and what the right sequence looks like.

A Quick Primer: What Each Treatment Does

PRP (Platelet-Rich Plasma) for Hair Loss

PRP is prepared from the patient’s own blood. Approximately 30-60ml of blood is drawn, then centrifuged to separate red blood cells from the platelet-rich plasma. The resulting PRP contains 4-8x the normal concentration of platelets, which release a cocktail of autologous (your own) growth factors when activated:

• PDGF (Platelet-Derived Growth Factor): Stimulates proliferation of dermal papilla cells — the cells that control hair follicle growth cycles.
• TGF-beta (Transforming Growth Factor beta): Modulates follicular inflammation and collagen production in the perifollicular matrix.
• EGF (Epidermal Growth Factor): Stimulates keratinocyte proliferation, supporting hair shaft production.
• VEGF (Vascular Endothelial Growth Factor): Promotes angiogenesis — new blood vessel formation around follicles — improving nutrient delivery.
• IGF-1 (Insulin-like Growth Factor 1): Supports follicle cell survival and anagen phase prolongation.
• HGF (Hepatocyte Growth Factor): Promotes hair shaft elongation and inhibits apoptosis in hair matrix cells.

A systematic review in Dermatologic Surgery confirmed PRP significantly increases hair density and thickness in androgenetic alopecia patients across multiple controlled trials. The treatment is well-tolerated, uses the patient’s own biology, and has essentially no allergy or rejection risk.

QR678 Neo: The Engineered Growth Factor Cocktail

QR678 Neo is a patented, standardised growth factor formulation developed and validated in clinical research. Unlike PRP, which uses the patient’s own growth factors (with variable concentrations between patients and sessions), QR678 Neo delivers a precisely calibrated combination of:

• VEGF: In a specific concentration optimised for follicular angiogenesis and papilla vascularisation.
• bFGF (Basic Fibroblast Growth Factor): A potent stimulator of dermal papilla cell proliferation and anagen phase prolongation. Not a significant component of PRP.
• EGF: In the formulation at concentrations specifically studied for hair follicle biology.
• IGF-1: Supporting anti-apoptotic effects on follicular cells under DHT stress.
• Additional proprietary components targeting follicular miniaturisation pathways.

The key distinction from PRP: QR678 Neo delivers standardised, reproducible growth factor concentrations every session. PRP concentrations vary between individuals (some patients are “low responders” with naturally low platelet growth factor content) and between sessions. For patients who are PRP low-responders, QR678 Neo provides guaranteed therapeutic concentrations regardless of individual platelet biology.

The Synergy Argument: Why Combining Makes Biological Sense

The case for combination therapy is built on two observations:

Complementary Growth Factor Profiles

PRP and QR678 Neo do not merely duplicate each other. They overlap significantly in some factors (VEGF, EGF, IGF-1) but each contributes unique elements:

Priming and Amplification Effect

The second reason combination works well is the priming effect. When PRP is administered first, PDGF and TGF-beta from platelets:

1. Rapidly increase local vascularisation around follicles (VEGF from PRP)
2. Create an environment of active fibroblast and dermal papilla cell proliferation
3. Increase the expression of growth factor receptors on dermal papilla cells

QR678 Neo administered into this already-primed, vascularised, receptor-upregulated environment may achieve better follicular uptake and cellular response than when administered alone into an un-primed environment. This is the proposed mechanism of synergy, though controlled clinical trials specifically examining the combination sequence are still emerging.

The Optimal Sequence: What the Evidence and Clinical Practice Suggest

Several sequencing approaches are used in clinical practice. The rationale for each:

Option A: PRP First, QR678 Neo Same Session (2-4 Weeks Later)

PRP is administered first to create the growth-factor-primed environment. QR678 Neo follows either immediately or at the next session (2-4 weeks) to add its specific growth factor profile to the already-activated follicular environment. Most commonly used in combined protocol practice.

Option B: Alternating Sessions

PRP and QR678 Neo are alternated — one treatment per month, rotating between them. This maintains a continuous presence of growth factors across different profiles throughout the treatment course without overloading the scalp in a single session. Useful for patients who prefer to spread the cost over time while maintaining treatment momentum.

Option C: Concurrent Injection (Same Session, Different Areas)

Both treatments can be administered in the same session, targeting different scalp zones or the same zones in layers. Technically more complex and dependent on the clinic’s preparation capabilities. Some physicians prefer this for patients with limited scheduling availability.

Who Benefits Most from Combination Therapy?

• Moderate to significant hair loss (Norwood 3-5, Ludwig 2-3): Where single-modality therapy may not be sufficient to arrest progression and stimulate meaningful regrowth simultaneously.
• PRP low-responders: Patients whose platelet growth factor content is naturally low (identifiable if PRP alone produced minimal results). QR678 Neo guarantees therapeutic growth factor concentrations regardless of platelet biology.
• Patients with slow response to monotherapy: Those who have completed a full PRP or QR678 Neo course but want to accelerate or enhance results.
• Patients with active miniaturisation who want aggressive stabilisation: Combination with oral medications (finasteride, dutasteride, oral minoxidil) plus dual injectable growth factor therapy provides the most comprehensive follicular environment optimisation.
• Post-transplant patients: PRP and QR678 Neo combination is used to improve graft survival and activate native follicles in adjacent areas after hair transplant surgery.

Setting Realistic Expectations for Combination Therapy

Combination therapy produces better results than monotherapy — but it is important to understand what “better” means quantitatively:

• Faster onset: Visible improvement typically appears after 3-4 combined sessions versus 5-6 for monotherapy.
• Greater density improvement: Clinical observations suggest 30-40% better hair density outcomes with combination compared to either alone, though head-to-head randomised controlled trials are still being published.
• Longer maintenance window: The synergistic effect on follicular vascularisation and papilla cell activity may produce a longer window before maintenance sessions are needed.
• Still not permanent without maintenance: Androgenetic alopecia is a chronic, progressive condition. Combination therapy does not cure it — it manages it more aggressively. Maintenance sessions are still required, though their frequency may be reduced.

Supporting Combination Therapy: What to Do Between Sessions

Injectable treatments alone are not the complete picture. The following adjuncts significantly enhance combination therapy outcomes:

1. Oral DHT blockers: Finasteride or dutasteride stops the hormonal damage that is working against your growth factor injections. Combination therapy without addressing DHT is fighting with one hand tied behind your back.
2. Oral or topical minoxidil: Increases follicular blood flow and prolongs anagen phase — directly complementary to the vascularisation effects of PRP and QR678 Neo.
3. Adequate protein intake: Hair is essentially keratinised protein. Without 1.2-1.6g protein per kg of body weight daily, follicles cannot build adequate shaft structure even with optimal growth factor stimulation.
4. Correcting nutritional deficiencies: Iron, vitamin D, zinc, and biotin deficiencies directly impair hair growth regardless of growth factor availability. Test before assuming supplementation is needed.
5. Sleep and stress management: Cortisol from chronic stress is a potent follicular suppressor. Growth factors work best when the systemic hormonal environment is not actively opposing them.

Frequently Asked Questions